Likely Connections and Potential Uses
Alzheimer's, Dementia
Alzheimer's, Dementia
Alzheimer's, Dementia
Biologic Agent Modifier:
MCP-1, CB2
Likely Synergistic Agents:
Spilantol - MCP-1
Caryophyllene - MCP-1, CB2
Research Indicates:
Research suggests that people with the lowest MCP-1 levels have the least memory loss. Spilanthol and Caryophyllene are shown to lower MCP-1.
Pain
Alzheimer's, Dementia
Alzheimer's, Dementia
Biologic Agent Modifier:
TRPA1,CB2,Glutathione
Likely Synergistic Agents:
Splilanthol - TRPA1
Caryophyllene - CB2
Dexpanthenol -Glutathione
Research Indicates: Pain is amplifed by reactive oxygen species "damaging tissues." Blocking the TRPA1 amplifier will lessen the pain response. Dexpanthenol increases glutathione which reduces reactive oxygen species and, thus, pain response.
Itch
Alzheimer's, Dementia
Wound Healing
Biologic Agent Modifier:
TRPA1, Keratinocytes, beta-endorphins, histamine/mast cells
Likely Synergistic Agents:
Spilanthol - TRPA1.Beta-endorphins, NFkB
Caryophyllene - Beta-endorphins
Research Indicates: Spilanthol inhibits mast cells from producing histamines which are responsible for typical itch. It also addresses non-histaminergic (neuropathic) itch through NFkB
Wound Healing
Post Traumatic Stress Disorder
Wound Healing
Biologic Agent Modifier:
TGF-beta
Likely Synergistic Agents: Spilanthol - TNFa
Research Indicates: Spilanthol is known to reduce TNFa which allows natural TGF-beta to continue wound healing and, according to Liarte, contributes
to healthy skin homeostasis.
Addictive Behaviors
Post Traumatic Stress Disorder
Post Traumatic Stress Disorder
Biologic Agent Modifier:
CB2 and mu-opioid
Likely Synergistic Agents:
Caryophyllene - CB2
Spilanthol - beta endorphin
Research Indicates:
Addiction reward was subdued in testing on mice, thus reducing addictive behavior.
Post Traumatic Stress Disorder
Post Traumatic Stress Disorder
Post Traumatic Stress Disorder
Biologic Agent Modifier:
CB2,TRPA1
Likely Synergistic Agents:
Caryophyllene - CB2
Spilanthol - TRPA1
Research Indicates:
PTSD brains are known to have elevated inflammation. Caryophyllene and Spilanthol act on inflammation.
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