NeoHack Secures Two Patents for Formulations and Methods of Achieving Pain Relief
Targeting the True Cause of Inflammation and Pain
Synergistic Combinations of Natural Ingredients Produce Surprising Results
Synergistic Combinations of Natural Ingredients Produce Surprising Results
NeoHack's topical formulation, unlike current pain and itch creams, naturally attacks "non-homeostasis" and associated inflammation -- the true source of chronic pain, itch and other maladies -- and helps the body return to its healthy "set point". Review our Research page under the menu tab "More" for supportive studies.
Synergistic Combinations of Natural Ingredients Produce Surprising Results
Synergistic Combinations of Natural Ingredients Produce Surprising Results
Synergistic Combinations of Natural Ingredients Produce Surprising Results
Newly patented combinations of natural and nature-identical ingredients have proven to be much more effective at reducing inflammation and pain than each ingredient when taken on its own.
Next Generation Topical Treatments are Absorbed in New Ways
Synergistic Combinations of Natural Ingredients Produce Surprising Results
Next Generation Topical Treatments are Absorbed in New Ways
NeoHack's patented formulations work through the blood stream and act more quickly, synergistically and effectively than typical creams and gels.
Our Formulations Focus on These Biological Targets
CB2
Modulating the CB2 receptor could be a game changer for memory loss in Alzheimer's as well as calming a wide variety of chronic inflammatory conditions.
TRPA1
TRPA1 is an essential transduction ion channel expressed in sensory neurons of the dorsal root ganglia and is involved in acute and inflammatory pain.
TRPV1
TRPV1 is an ion channel recognized for its sensing of pain. It has been pursued in the past as a target for pain relief with uncertain results due to unpleasant side effects.
TRPM8
TRPM8 acts as the human cold sensor and is important to neurovascular pathways. Unfortunately, TRPM8 declines as the body ages and can trigger a variety of chronic, painful conditions.
Antioxidant Pathway
Antioxidant Pathway
It is through the antioxidant pathway that NeoHack's formulations increase a tripeptide that plays a critical role in defending the brain against aging and neurodegeneration.
Stroke Prevention
Antioxidant Pathway
Our Most Recent Patents Reveal Potential Stroke Prevention Methods and Formulations
Our two most recently published patents (link https://neohacksciences.com/newest-patents.) cover both methods and formulations with over 20 claims.
Stroke is associated with these disorders listed in the patents: type 2 diabetes, acute inflammation, blood
Our Most Recent Patents Reveal Potential Stroke Prevention Methods and Formulations
Our two most recently published patents (link https://neohacksciences.com/newest-patents.) cover both methods and formulations with over 20 claims.
Stroke is associated with these disorders listed in the patents: type 2 diabetes, acute inflammation, blood pressure deviation, viral infections, and bacterial infections. Each condition contributes to stroke risk through distinct physiological mechanisms that impact the cardiovascular system. (link https://pmc.ncbi.nlm.nih.gov/articles/PMC11786524/)
The methods covered in the May 2025 patent includes easy to administer methods such as lozenges.
The formulations covered in the July 2025 patent use FEMA GRAS approved ingredients (https://www.femaflavor.org/gras) for safety. Key components cited include the following:
1. Beta Caryophyllene
2. Dexpanthenol
3. Spilanthol
4. Pellitorine
In the article referenced below, we have focused on the ability of our herbal based components to inhibit ICAM-1 and VCAM-1 which reduce the oxidative damage in the aftermath of loss of blood.
Certain cytokines are cited that our herbal components limit TNFa, INOS, IL-1, NLRP3, PI3K/AKT, p38MAPK, MMP's and VEGF-1 et al, all causing extensive oxidative damage.
(The review article in Frontiers in Cellular Science by Fu, X. et al, 2025, DOI 10.3389/fricel.2025.1536028)
Each of the following five disorders are cited in the patents in claims 9 and 12:
1. Diabetes type 2
Type 2 diabetes significantly increases the risk of stroke, with studies showing that people with diabetes Dave more than double the risk compared to non-diabetics.
- Accelerates atherosclerosis: High blood sugar levels can damage blood vessels over time, leading to fatty deposits and the narrowing of arteries. This is the primary mechanism for the increased risk of ischemic stroke.
- Worsens outcomes: In diabetic patients, both acute hyperglycemia during a stroke and chronic poor glycemic control are linked to worse clinical outcomes and higher mortality.
2. Acute inflammation
Acute inflammation is both a risk factor for and a consequence of ischemic stroke.
- Triggers stroke: A strong inflammatory response can trigger a stroke by causing plaque rupture, which leads to a clot. It can also create a prothrombotic, or clot-forming, state.
- Exacerbates brain damage: Following a stroke, the brain's inflammatory response can worsen tissue damage, increase blood-brain barrier permeability, and lead to brain edema.
3. Blood pressure deviation
High blood pressure is the most important and common modifiable risk factor for stroke.
- Sustained high pressure: Chronic, uncontrolled high blood pressure puts constant strain on artery walls, which can weaken them and lead to a hemorrhagic stroke (a bleed) or make them more susceptible to blockages causing an ischemic stroke.
- High variability: Significant day-to-day or visit-to-visit fluctuations in blood pressure, known as blood pressure variability (BPV), are also independently associated with a higher risk of stroke.
4. Viral infections
Viral infections, whether acute or chronic, can increase stroke risk through several mechanisms.
- Acute infection: Severe infections like influenza and COVID-19 are linked to a temporary, elevated risk of stroke. They can trigger inflammation and increase the risk of blood clots.
- Chronic infection: Persistent infections, such as those caused by herpesviruses (e.g., varicella-zoster virus) and HIV, have been associated with cerebral vasculopathy, where the viruses invade and damage the blood vessel walls.
5. Bacterial infections
Bacterial infections are also associated with an increased risk of stroke, especially in the short-term following an acute infection.
Inquiries:
We invite inquiries for further information about acquiring licensing to use our patented methods and formulation via this link https://neohacksciences.com/contact-and-license
Stroke Prevention
Stroke Prevention
Stroke Prevention
Our Most Recent Patents Reveal Potential Stroke Prevention Methods and Formulations
Our two most recently published patents (link https://neohacksciences.com/newest-patents.) cover both methods and formulations with over 20 claims.
Stroke is associated with these disorders listed in the patents: type 2 diabetes, acute inflammation, blood
Our Most Recent Patents Reveal Potential Stroke Prevention Methods and Formulations
Our two most recently published patents (link https://neohacksciences.com/newest-patents.) cover both methods and formulations with over 20 claims.
Stroke is associated with these disorders listed in the patents: type 2 diabetes, acute inflammation, blood pressure deviation, viral infections, and bacterial infections. Each condition contributes to stroke risk through distinct physiological mechanisms that impact the cardiovascular system. (link https://pmc.ncbi.nlm.nih.gov/articles/PMC11786524/)
The methods covered in the May 2025 patent includes easy to administer methods such as lozenges.
The formulations covered in the July 2025 patent use FEMA GRAS approved ingredients (https://www.femaflavor.org/gras) for safety. Key components cited include the following:
1. Beta Caryophyllene
2. Dexpanthenol
3. Spilanthol
4. Pellitorine
In the article referenced below, we have focused on the ability of our herbal based components to inhibit ICAM-1 and VCAM-1 which reduce the oxidative damage in the aftermath of loss of blood.
Certain cytokines are cited that our herbal components limit TNFa, INOS, IL-1, NLRP3, PI3K/AKT, p38MAPK, MMP's and VEGF-1 et al, all causing extensive oxidative damage.
(The review article in Frontiers in Cellular Science by Fu, X. et al, 2025, DOI 10.3389/fricel.2025.1536028)
Each of the following five disorders are cited in the patents in claims 9 and 12:
1. Diabetes type 2
Type 2 diabetes significantly increases the risk of stroke, with studies showing that people with diabetes Dave more than double the risk compared to non-diabetics.
- Accelerates atherosclerosis: High blood sugar levels can damage blood vessels over time, leading to fatty deposits and the narrowing of arteries. This is the primary mechanism for the increased risk of ischemic stroke.
- Worsens outcomes: In diabetic patients, both acute hyperglycemia during a stroke and chronic poor glycemic control are linked to worse clinical outcomes and higher mortality.
2. Acute inflammation
Acute inflammation is both a risk factor for and a consequence of ischemic stroke.
- Triggers stroke: A strong inflammatory response can trigger a stroke by causing plaque rupture, which leads to a clot. It can also create a prothrombotic, or clot-forming, state.
- Exacerbates brain damage: Following a stroke, the brain's inflammatory response can worsen tissue damage, increase blood-brain barrier permeability, and lead to brain edema.
3. Blood pressure deviation
High blood pressure is the most important and common modifiable risk factor for stroke.
- Sustained high pressure: Chronic, uncontrolled high blood pressure puts constant strain on artery walls, which can weaken them and lead to a hemorrhagic stroke (a bleed) or make them more susceptible to blockages causing an ischemic stroke.
- High variability: Significant day-to-day or visit-to-visit fluctuations in blood pressure, known as blood pressure variability (BPV), are also independently associated with a higher risk of stroke.
4. Viral infections
Viral infections, whether acute or chronic, can increase stroke risk through several mechanisms.
- Acute infection: Severe infections like influenza and COVID-19 are linked to a temporary, elevated risk of stroke. They can trigger inflammation and increase the risk of blood clots.
- Chronic infection: Persistent infections, such as those caused by herpesviruses (e.g., varicella-zoster virus) and HIV, have been associated with cerebral vasculopathy, where the viruses invade and damage the blood vessel walls.
5. Bacterial infections
Bacterial infections are also associated with an increased risk of stroke, especially in the short-term following an acute infection.
Inquiries:
We invite inquiries for further information about acquiring licensing to use our patented methods and formulation via this link https://neohacksciences.com/contact-and-license
Natural Synergistic Components
Spilanthol - Targets TRPA1
Active ingredient "spilanthol" is derived from the spilanthese flower, also called the "toothache" plant due to its anti-inflammatory and pain killing properties.
Caryophyllene- Targets CB2
Active ingredient caryophyillene is best derived from the sap of the copaiba tree. It has been shown to have anti-inflammatory properties linked to its affect on critical CB2 receptors.
Pellitorine - Targets TRPA1 and TRPV1
Pellitorine is a natural product found in black pepper plants, among others. It has long been associated with reversing inflammation, treating diseases of the central nervous system, and has been identified by the NIH as a potential anti-cancer compound.
Menthol - Targets TRPM8
Menthol, derived from the common peppermint plant, is widely known for relieving pain and calming respiratory conditions, but also helps heal wounds and reverses inflammation.
Dexpanthenol - Targets Antioxidant Pathways
Dexpanthenol is a precursor or alcohol derivative of Vitamin B5. Consumers often see it in topical healing ointments and creams, but it also contains valuable anti-inflammatory properties. Perhaps more importantly, it acts to boost a key tripeptide -- glutathiome -- that helps protect the brain against damage caused by aging and neurodegeneration.
Restoring Homeostasis is the Singular Objective
Current Research Underway
Alzheimer's
Immunology
Inflammation
Migraine Headaches
Peripheral Neuropathy
Herbal Components
Non-addictive pain relief
Developing Treatment "Carriers" or vehicles (see pending patent)
Skin cream lotion
Oral Gel
Joint Pain Cream
Anti-inflammatory Cream
Oral Compressed Tablet
Lozenge
Oral Conditioning Rinse
Lip Balm
Pain Relieving Nasal Spray
Anal Suppository