Dementia markers in the brain and living environment influences
October 28, 2025
Researchers at Wake Forest University School of Medicinehave produced an amazing piece of work recently published with the title, Associations of place-based social determinants of health with biomarkers of Alzheimer's disease and related dementias.[1] The link to the publication is included here. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/bsa3.70030
The INTRODUCTION identifies social determinants of health (SDoH) defined as “where people live, work, play and age” and “the overlapping effects of race and place on health have been studied extensively”.
We have posted blogs on our website, https://neohacksciences.com/, making the connection between chronic inflammation and neurodegenerative disorders dealt within our most recent patents issued published in May and July 2025 by the USPTO. https://neohacksciences.com/newest-patents.
We believe that any insult to the brain results in an inflammatory response.
Chronic inflammation is a prolonged state of inflammation that can last for weeks, months, or even years. Addressing inflammation is essential for treating many disorders.
The May patent contains 20 claims for methods of treating pain and resulting conditions for certain disorders including Alzheimer’s Disease. The July patent covers formulations for the same disorders.
We believe by using components deemed safe for inclusion in the food chain and methods easily produced, a treatment can be widely distributed at affordable prices and can have a huge positive impact on place-based SDoH.
Footnotes:
1Krishnamurthy, S., et al. (2025) Associations of place-based social determinants
of health with biomarkers of Alzheimer's disease and related dementias.
Alzheimer's & Dementia: Behavior & Socioeconomics of Aging.
Full Disclosure: Our CEO Ron Butler earned the MBA degree from the Wake Forest School of Business and served for 20 years on its Board of Visitors but has no association with its School of Medicine or any of the named authors.
The Brain and Neuroinflammation
"Everything we do, every thought we've ever had, is produced by the human brain. But exactly how it operates remains one of the biggest unsolved mysteries, and it seems the more we probe its secrets, the more surprises we find" — BrainyQuote Neil deGrasse Tyson
The brain is amazing in terms of what it does and can do to help our bodies remain in the healthy set point called homeostasis. Unfortunately, the brain can be subjected to injury, infection, disease, or excessive inflammation.
One study from 2018 indicated that out of 22.6 million patients with neurological disorders, 13.8 million required surgery, according to Centers for Neurosurgery Spine & Orthopedics.
Neuroinflammation is an immune response within the central nervous system (CNS), triggered by injury, infection, or disease, involving activated immune cells like microglia and astrocytes and can be a beneficial response to protect the brain. However, if it persists it can lead to chronic low-grade irritation.
Neuroinflammation can be a beneficial response to protect the brain by helping remove pathogens and clear damaged cells and debris thus protecting the healthy set point of homeostasis.
If the inflammation persists or is not adequately controlled, it can lead to chronic, low-grade irritation, resulting in ongoing damage to brain tissue and neurodegeneration.
Neuroinflammation can damage the blood-brain barrier (BBB), potentially allowing peripheral immune cells to enter the CNS and exacerbate the inflammation.
Neurotoxicity can result in free radicals and other inflammatory byproducts that can damage neurons and other CNS cells.
While initially a protective mechanism to clear debris and fight pathogens, chronic or uncontrolled neuroinflammation can cause damage, leading to neurodegeneration and contributing to diseases such as Alzheimer's and Parkinson's disease.
Our most recent patents are instrumental in stopping excessive neuroinflammation.
See our patents section via this link https://neohacksciences.com/newest-patents
